Clinical changes induced by allergen immunotherapy with dermatophagoides pteronyssinus in local allergic rhinitis
نویسندگان
چکیده
Methods Thirty-six subjects with LAR to DP were selected to participate in a double-blind, placebo-controlled, parallelgroup, phase II clinical trial of subcutaneous AIT in LAR. The patients were randomized to receive AIT-DP with Pangramin PLUS, ALK, DP, or placebo for a period of 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints were: total combined symptom+medication scores (TCS), daily symptoms score (DSS), daily medication score (DMS), medication free days (MFD), skin testing, nasal allergen provocation test (NAPT-DP), and adverse events. Serum and nasal lavage samples were obtained for immunological studies.
منابع مشابه
Prevalence of Common Aeroallergens in Patients with Allergic Rhinitis in Gorgan, North of Iran, Based on Skin Prick Test Reactivity
Background Allergic rhinitis is one of the most common types of rhinitis. Allergen avoidance is the most important way of preventing this disease. The present study is carried out to determine the frequency of common aeroallergens in patients with allergic rhinitis in Gorgan city by skin prick test (SPT) reactivity. Materials and Methods In this cross-sectional study 270 patients referring t...
متن کاملHypersensitivity to House Dust Mite and Cockroach Is the Most Common Allergy in North of Iran
Background: Asthma and allergic rhinitis are among the most common diseases in the world. Objective: The aim of this study was to detect, by skin prick test, aeroallergens in allergic patients in Sari, Mazandaran in north of Iran. Methods: This is a prospective study of skin prick test of aeroallergens in asthma, allergic rhinitis and their combination with clinical diagnosis. Three hundred and...
متن کاملSkin Prick Test Reactivity to Common Aero and Food Allergens among Children with Allergy
Background: The prevalence of allergic diseases has risen in the last decades. The objective of this study was to determine the common allergens in children via the skin prick test.Methods: This cross-sectional study recruited 313 allergic children (4 months to 18 years old) referred to the Asthma and Allergy Clinic of Children’s Medical Center in Tehran. A questionnaire containing demographic ...
متن کاملSubcutaneous allergen immunotherapy with dermatophagoides pteronyssinus in patient with local allergic rhinitis
Methods A randomized, double-blind, placebo-controled, parallelgroup, phase II study was conducted. Thirty-six subjects with LAR to DP were randomized to receive Pangraminâ PLUS, ALK, Dermatophagoides pteronyssinus (AIT-DP) or placebo for 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints included: total combined symptom+medication sc...
متن کاملSafety of specific subcutaneous immunotherapy in patients with allergic rhinitis
Methods We conducted a retrospective, longitudinal study evaluating patients with AR, over the age of three, who were using SCIT with extracts of D pteronyssinus (Dp) and/or B tropicalis (Bt) (FDA Allergenic). Data were collected through interviews and medical records. The classification of the severity of adverse reactions met the criteria established by the Allergen Immunotherapy: a Practice ...
متن کاملEfficacy and safety of specific immunotherapy with a modified mite extract
Background: In specific immunotherapy (SIT), modified extracts have been used to allow safe administration of higher allergen doses. Schedules reaching maintenance doses in approximately 1 month, which may have greater efficacy, have even been proposed. Aims: To assess the safety and efficacy of SIT with modified (depigmented and polymerized) Dermatophagoides pteronyssinus extract in the treatm...
متن کامل